Article
Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1.
RNA (New York, N.Y.) - 1 Sept 1998
Mayeda A, Munroe S H, Xu R M, Krainer A R
Abstract excerpt
hnRNP A1 regulates alternative splicing by antagonizing SR proteins. It consists of two closely related, tandem RNA-recognition motifs (RRMs), followed by a glycine-rich domain. Analysis of variant proteins with duplications, deletions, or swaps of the RRMs showed that although both RRMs are requ...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Conserved Sequence
- Escherichia coli
- Evolution, Molecular
- Genetic Variation
- Heterogeneous Nuclear Ribonucleoprotein A1
- Heterogeneous-Nuclear Ribonucleoprotein Group A-B