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Article

Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2012

Schmidt-Strassburger Uta, Schips Tobias G, Maier Harald J, Kloiber Katharina, Mannella Francesca, Braunstein Kerstin E, Holzmann Karlheinz, Ushmorov Alexey, Liebau Stefan, Boeckers Tobias M, Wirth Thomas

Abstract excerpt

Inactivation of FoxO proteins by phosphorylation is the result of a number of stimuli, including the insulin/IGF pathway. We were interested in the consequence of blunting this pathway by employing transgenic mice with tetracycline-controllable conditional expression of a constitutively active al...

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Source

Identifiers

PMID: 22935140
DOI: 10.1096/fj.12-208587

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22935140-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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