Article
Molecular genetics of ovarian carcinomas.
Histology and histopathology - 1 Jan 1999
Diebold J
Abstract excerpt
The phenotypic variability of epithelial ovarian neoplasms correlates with a diversity of changes at the molecular level. Invasive serous and undifferentiated ovarian carcinomas are characterized by p53 mutations with p53 protein accumulation, extensive loss of genetic material of chromosome 17 and complex changes on many other chromosomes, e.g. amplification of oncogenes. These alterations are seen only in a...
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