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Article

[The role of major histocompatibility complex genes in the pathogenesis of chronic inflammatory bowel diseases].

La Tunisie medicale - 1 May 2003

Matri Samira, Boubaker Jalel, Hamzaoui Samir, Bardi Rafika, Ayed Khaled, Filali Azza

Abstract excerpt

Genetic factors, among which the HLA class II coding genes, are implicated in IBD pathogenesis. When considering the ethnic heterogeneity of the studied population and the IBD clinical heterogeneity, UC appears more dependent to HLA genes than CD. UC and HLA genes: HLA DR 4 gene would protect from UC. HLA DR2 gene, particularly the DRB 1 * 1502 allele, is predisposing for more severe forms necessitating a...

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PMID: 12934447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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