Article
Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene.
The Journal of biological chemistry - 2 May 1997
Liu X F, Supek F, Nelson N, Culotta V C
Abstract excerpt
We have previously shown that mutations in the Saccharomyces cerevisiae BSD2 gene suppress oxidative damage in cells lacking superoxide dismutase and also lead to hyperaccumulation of copper ions. We demonstrate here that bsd2 mutant cells additionally accumulate high levels of cadmium and cobalt. By biochemical fractionation and immunofluorescence microscopy, BSD2 exhibited localization to the endoplasmic...
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