Article
Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response.
FEMS yeast research - 1 Feb 2013
Ríos Gabino, Cabedo Marc, Rull Baltasar, Yenush Lynne, Serrano Ramón, Mulet José M
Abstract excerpt
We have identified QDR2 in a screening for genes able to confer tolerance to sodium and/or lithium stress upon overexpression. Qdr2 is a multidrug transporter of the major facilitator superfamily, originally described for its ability to transport the antimalarial drug quinidine and the herbicide barban. To identify its physiological substrate, we have screened for phenotypes dependent on QDR2 and found that Qdr2...
Topics
- Biological Transport
- Cadmium
- Calcium
- Cations, Divalent
- Cations, Monovalent
- Cobalt
- Copper
- Gene Deletion
- Gene Expression Regulation, Fungal
- Homeostasis
- Hydrogen Peroxide
- Lithium
- Membrane Transport Proteins
- Oxidation-Reduction