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Article

Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function.

The Journal of cell biology - 2 Aug 2004

Ellis Charissa D, Wang Fudi, MacDiarmid Colin W, Clark Suzanne, Lyons Thomas, Eide David J

Abstract excerpt

In this report, we show that zinc is required for endoplasmic reticulum function in Saccharomyces cerevisiae. Zinc deficiency in this yeast induces the unfolded protein response (UPR), a system normally activated by unfolded ER proteins. Msc2, a member of the cation diffusion facilitator (CDF) family of metal ion transporters, was previously implicated in zinc homeostasis. Our results indicate that Msc2 is one...

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Identifiers

PMID: 15277543
DOI: 10.1083/jcb.200401157
PMCID: PMC2172251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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