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Article

Mutation of RET codon 768 is associated with the FMTC phenotype.

Clinical genetics - 1 Feb 1997

Boccia L M, Green J S, Joyce C, Eng C, Taylor S A, Mulligan L M

Abstract excerpt

Multiple endocrine neoplasia type 2A (MEN 2A), type 2B (MEN 2B), and familial medullary thyroid carcinoma (FMTC) are inherited cancer syndromes resulting from mutations in the RET proto-oncogene. Missense mutations of five codons in exons 10 and 11 are found in both MEN 2A and FMTC families, whil...

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Source

Identifiers

PMID: 9111992
DOI: 10.1111/j.1399-0004.1997.tb02424.x

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9111992-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of RET codon 768 is associated with the FMTC phenotype.PMID 9111992Read ↗

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.Semantic proximity Read ↗

The RET mutation E768D confers a late-onset familial medullary thyroid carcinoma -- only phenotype with incomplete penetrance: implications for screening and management of carrier status.Semantic proximity Read ↗

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.Semantic proximity Read ↗

A RET double mutation in the germline of a kindred with FMTC.Semantic proximity Read ↗

Change in the spectrum of RET mutations diagnosed between 1994 and 2006.Semantic proximity Read ↗

Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.Semantic proximity Read ↗

RET proto-oncogene mutations are restricted to codon 634 and 618 in Korean families with multiple endocrine neoplasia 2A.Semantic proximity Read ↗

The RET E616Q Variant is a Gain of Function Mutation Present in a Family with Features of Multiple Endocrine Neoplasia 2A.Semantic proximity Read ↗

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2.Semantic proximity Read ↗

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.Semantic proximity Read ↗

RET proto-oncogene mutations in French MEN 2A and FMTC families.Semantic proximity Read ↗

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