Article
Change in the spectrum of RET mutations diagnosed between 1994 and 2006.
Clinical laboratory - 1 Jan 2007
Frank-Raue Karin, Rondot Susanne, Schulze Egbert, Raue Friedhelm
Abstract excerpt
Medullary thyroid carcinoma (MTC) is a rare calcitonin producing tumor. About 70-75% of patients with MTC have sporadic disease while the others suffer from hereditary MTC. Hereditary MTC is divided into three clinical subtypes: multiple endocrine neoplasia (MEN) type 2A is characterized by MTC, pheochromocytoma and primary hyperparathyroidism. MEN 2B is characterized by aggressive MTC, pheochromocytoma,...
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