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Article

Alternative models for early onset of childhood leukaemia.

The British journal of cancer. Supplement - 1 Aug 1992

Wheldon T E, Mairs R J, Barrett A, Wheldon E G, Gibson B E

Abstract excerpt

This paper considers theoretical models for early-onset childhood leukaemia. The major focus of attention is the two-hit mutational model. A simple mathematical representation is used to explore mechanisms which might lead to onset of leukaemia at an unusually early age. Two such mechanisms are considered. The first of these, a germinal or very early embryonic first mutation is shown to imply that multiple...

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Identifiers

PMID: 1503920
PMCID: PMC2149658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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