Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.

Carcinogenesis - 1 Dec 2011

Mahimkar Rajeev, Alfonso-Jaume Maria Alejandra, Cape Leslie M, Dahiya Rajvir, Lovett David H

Abstract excerpt

Activation of Raf/Ras/mitogen-activated protein kinase (MEK)/mitogen-activated protein kinase signaling and elevated expression of membrane type-1 matrix metalloproteinase (MT1-MMP) are associated with von Hippel-Lindau gene alterations in renal cell carcinoma. We postulated that the degree of MEK activation was related to graded expression of MT1-MMP and the resultant phenotype of renal epithelial tumors. Madin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Immunohistochemistry

Share to Kidney Neoplasms

Share to MAP Kinase Kinase 1

Share to Matrix Metalloproteinase 14

Source

Open in PubMed Open full text

Identifiers

PMID: 21965271
DOI: 10.1093/carcin/bgr216
PMCID: PMC3220610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.PMID 21965271Read ↗

Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells.Semantic proximity Read ↗

Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells.Semantic proximity Read ↗

Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells.Semantic proximity Read ↗

Membrane Type 1 Matrix Metalloproteinase Induces Epithelial-to-Mesenchymal Transition in Prostate CancerSemantic proximity Read ↗

Rho/Rho kinase pathway regulates maintenance of the differentiated tubular epithelial cell phenotype on laminin-1.Semantic proximity Read ↗

Clinical Evolution of Epithelial–Mesenchymal Transition in Human CarcinomasSemantic proximity Read ↗

Using 3D Invasion properties of RCC Cell Lines <i>In Vitro</i> to predict their Metastatic Potential <i>In Vivo</i>Semantic proximity Read ↗

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.