Article
Continuous in vitro evolution of catalytic function.
Science (New York, N.Y.) - 25 Apr 1997
Wright M C, Joyce G F
Abstract excerpt
A population of RNA molecules that catalyze the template-directed ligation of RNA substrates was made to evolve in a continuous manner in the test tube. A simple serial transfer procedure was used to achieve approximately 300 successive rounds of catalysis and selective amplification in 52 hours....
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