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Article

A molecular description of the evolution of resistance.

Chemistry & biology - 1 Dec 1999

Ordoukhanian P, Joyce G F

Abstract excerpt

BACKGROUND: In vitro evolution has been used to obtain nucleic acid molecules with interesting functional properties. The evolution process usually is carried out in a stepwise manner, involving successive rounds of selection, amplification and mutation. Recently, a continuous in vitro evolution system was devised for RNAs that catalyze the ligation of oligonucleotide substrates, allowing the evolution of...

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PMID: 10631516
DOI: 10.1016/s1074-5521(00)80007-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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