Article
Forty years of in vitro evolution.
Angewandte Chemie (International ed. in English) - 1 Jan 2007
Joyce Gerald F
Abstract excerpt
It has been 40 years since Spiegelman and co-workers demonstrated how RNA molecules can be evolved in the test tube. This result established Darwinian evolution as a chemical process and paved the way for the many directed evolution experiments that followed. Chemists can benefit from reflecting on Spiegelman's studies and the subsequent advances, which have taken the field to the brink of the generation of life...
Topics
- Animals
- DNA-Directed RNA Polymerases
- Directed Molecular Evolution
- Humans
- Phenotype
- RNA
- RNA, Catalytic
- Reverse Transcriptase Polymerase Chain Reaction