Article
Ornithine decarboxylase is directly involved in mouse mammary carcinoma cell invasion in vitro.
Biochemical and biophysical research communications - 28 Mar 1995
Kubota S, Yamada T, Kamei S, Seyama Y
Abstract excerpt
To elucidate the role of ornithine decarboxylase (ODC) in cancer cell invasion, we have compared the invasiveness of mouse mammary carcinoma, FM3A and its variant cell line, EXOD, which overproduces ODC. We have found that EXOD cells showed about 5.6-fold more invasiveness through a reconstituted basement membrane (Matrigel) compared to FM3A cells. To elucidate the underlying mechanism of increased invasiveness...
Topics
- Animals
- Antibodies
- Base Sequence
- Blotting, Northern
- Cell Adhesion
- Gelatinases
- Genetic Variation
- Mammary Neoplasms, Experimental
- Mice
- Molecular Sequence Data
- Molecular Weight