Article
Clinical and molecular diagnosis of multiple endocrine neoplasia type 1.
Langenbeck's archives of surgery - 1 Mar 2002
Karges Wolfram, Schaaf Ludwig, Dralle Henning, Boehm Bernhard O
Abstract excerpt
Multiple endocrine neoplasia type 1 (MEN1) is a classic hereditary tumor syndrome characterized by a genetic predisposition to develop a variety of neuroendocrine neoplasias and hormone excess syndromes. The disease is caused by inactivating mutations of the MEN1 tumor suppressor gene, detectable in >95% of MEN1 families. The distinction of MEN1-associated tumors from sporadic neuroendocrine neoplasias is...
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