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Article

Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype.

Breast cancer research and treatment - 1 May 2001

Milde-Langosch K, Bamberger A M, Rieck G, Kelp B, Löning T

Abstract excerpt

In order to study the role of the p16INK4A(MTS1/CDKN2a) tumor suppressor in breast cancer, we analyzed p16 protein expression in 60 breast cancer samples which were also analyzed for expression of Rb, Ki67, HER2/neu, and estrogen and progesterone receptors (ER, PR). P16 expression was investigated by two methods: western blotting (WB) followed by densitometry, and immunohistochemistry (IHC). The Rb status was...

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Identifiers

PMID: 11518467
DOI: 10.1023/a:1010623308275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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