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Article

Sequence analysis by hybridization with oligonucleotide microchip: identification of beta-thalassemia mutations.

Gene - 25 Mar 1997

Drobyshev A, Mologina N, Shik V, Pobedimskaya D, Yershov G, Mirzabekov A

Abstract excerpt

Diagnostics for genetic diseases were run and sequence analysis of DNA was carried out by hybridization of RNA transcripts with oligonucleotide array microchips. Polyacrylamide gel pads (100 x 100 x 20 microm) were fixed on a glass slide of the microchip and contained allele-specific immobilized oligonucleotides (10-mers). The RNA transcripts of PCR-amplified genomic DNA were fluorescently labeled by enzymatic or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9099858
DOI: 10.1016/s0378-1119(96)00775-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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