Article
A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.
American journal of human genetics - 1 Apr 2002
Eberle Michael A, Pfützer Roland, Pogue-Geile Kay L, Bronner Mary P, Crispin David, Kimmey Michael B, Duerr Richard H, Kruglyak Leonid, Whitcomb David C, Brentnall Teresa A
Abstract excerpt
Pancreatic cancer is the fifth leading cause of cancer death in the United States. Nearly every person diagnosed with pancreatic cancer will die from it, usually in <6 mo. Familial clustering of pancreatic cancers is commonly recognized, with an autosomal dominant inheritance pattern in approximately 10% of all cases. However, the late age at disease onset and rapid demise of affected individuals markedly hamper...
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