Article
Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia.
Schizophrenia research - 27 Jul 1998
Li T, Arranz M, Aitchison K J, Bryant C, Liu X, Kerwin R W, Murray R, Sham P, Collier D A
Abstract excerpt
The dopamine system has long been suspected of aetiological involvement in schizophrenia because of a number of lines of evidence pointing to excess dopaminergic activity in the illness. Recently, negative allelic association was reported between a single base deletion in the promoter region of t...
Topics
- Adolescent
- Adult
- Alleles
- Case-Control Studies
- China
- Female
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Genetic
- Receptors, Dopamine D2
- Risk Factors
- Schizophrenia