Article
Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia.
Schizophrenia research - 27 Jul 1998
Li T, Arranz M, Aitchison K J, Bryant C, Liu X, Kerwin R W, Murray R, Sham P, Collier D A
Abstract excerpt
The dopamine system has long been suspected of aetiological involvement in schizophrenia because of a number of lines of evidence pointing to excess dopaminergic activity in the illness. Recently, negative allelic association was reported between a single base deletion in the promoter region of the DRD2 gene, -141 delta C, and schizophrenia, with an odds ratio of 0.60. This was of particular interest since the...
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