Article
Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia.
Psychiatry research - 16 Nov 1998
Ohara K, Nagai M, Tani K, Nakamura Y, Ino A, Ohara K
Abstract excerpt
Several studies showed the density of D2 receptors was elevated in postmortem brains from schizophrenics. Genes which operate at the level of gene activation may be associated with the pathogenesis of schizophrenia. Arinami et al. [(1997) Human Molecular Genetics 6, 577-582] found a polymorphism...
Topics
- Adult
- Alleles
- Brain
- Chromosome Deletion
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Mutagenesis, Insertional
- Polymorphism, Genetic
- Prognosis
- Promoter Regions, Genetic
- Receptors, Dopamine D2
- Schizophrenia
- Schizophrenic Psychology