Article
In vivo packaging of bacteriophage lambda monomeric chromosomes.
Journal of molecular biology - 21 Mar 1997
Thomason L C, Thaler D S, Stahl M M, Stahl F W
Abstract excerpt
There is an apparent paradox between the reported requirements for lambda DNA packaging in vivo and in vitro. In vivo, DNA concatemers are required for packaging. On the other hand, in vitro, packaging extracts can encapsidate either linear or circular monomeric lambda DNA. Perhaps cellular nucleases restrict the in vivo ability of monomers to package by degrading a free double chain end present as an...
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