Article
Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.
Journal of human genetics - 1 May 2010
Kogo Hiroshi, Kowa-Sugiyama Hiroe, Yamada Kouji, Bolor Hasbaira, Tsutsumi Makiko, Ohye Tamae, Inagaki Hidehito, Taniguchi Mariko, Toda Tatsushi, Kurahashi Hiroki
Abstract excerpt
Prophase I of male meiosis during early spermatogenesis involves dynamic chromosome segregation processes, including synapsis, meiotic recombination and cohesion. Genetic defects in the genes that participate in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility in humans, we performed gene expression profiling of mouse spermatogenic cells...
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