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Article

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.

FEBS letters - 24 Mar 1997

Sami M, Brown T J, Roach P L, Schofield C J, Baldwin J E

Abstract excerpt

The non-heme ferrous dependent oxidase isopenicillin N synthase (IPNS) catalyses the biosynthesis of isopenicillin N from a tripeptide substrate. The crystal structure of Aspergillus nidulans IPNS complexed to manganese reveals a six co-ordinate metal ligated by two water molecules and four protein ligands: His-214, His-270, Asp-216 and Gln-330 (the penultimate C-terminal residue). Modification of Gln-330 to Ala...

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PMID: 9089289
DOI: 10.1016/s0014-5793(97)00176-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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