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Article

Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu.

Archives of biochemistry and biophysics - 15 Jan 2008

Graham Stephen C, Guss J Mitchell

Abstract excerpt

Aminopeptidase P (APPro) is a manganese-containing enzyme that catalyses the hydrolysis of the N-terminal residue of a polypeptide if the second residue is proline. Structures of APPro mutants with reduced or negligible activity have been determined in complex with the tripeptide substrate ValProLeu. In the complex of Glu383Ala APPro with ValProLeu one of the two metal sites is only partly occupied, indicating an...

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PMID: 17983589
DOI: 10.1016/j.abb.2007.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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