Article
Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach.
Genes, chromosomes & cancer - 1 Apr 1997
Sakata K, Tamura G, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R
Abstract excerpt
During an allelotype analysis of differentiated adenocarcinoma of the stomach, we observed frequent loss of heterozygosity (LOH) on several chromosomes including the long arm of chromosome 21 (21q). Therefore, we analyzed DNA isolated from 45 tumors for LOH at 10 loci on 21q by using polymorphic microsatellite markers. In 20 (44%) of 45 tumors, we detected LOH at single or multiple loci on 21q. Deletion mapping...
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