TSH Receptor Transcripts and TSH Receptor-like Immunoreactivity in Orbital and Pretibial Fibroblasts of Patients with Graves' Ophthalmopathy and Pretibial Myxedema

Abstract excerpt

Several lines of experimental and clinical evidence favor a close etiologic link between Graves' disease and its associated extrathyroidal manifestations, ophthalmopathy and pretibial dermopathy. The human TSHR represents a candidate antigen shared between the thyroid gland and the involved extrathyroidal sites in Graves' disease. Here, we demonstrate that ribonucleic acid encoding exons 1-10 of human TSHR can be...