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Article

Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues.

The Journal of clinical endocrinology and metabolism - 1 Nov 1994

Paschke R, Metcalfe A, Alcalde L, Vassart G, Weetman A, Ludgate M

Abstract excerpt

The TSH receptor (TSHR) has been proposed as an antigenic link between the thyroid and the orbit; TSHR transcripts have been demonstrated by other groups, one in orbital tissue and the other in orbital and dermal fibroblasts. In a previous study we were unable to demonstrate transcripts for the complete TSHR in retroocular muscle containing also fibroblasts. We now confirm this finding. A 1.3-kilobase variant of...

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Source

Identifiers

PMID: 7962314
DOI: 10.1210/jcem.79.5.7962314

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues.PMID 7962314Read ↗

TSH Receptor Transcripts and TSH Receptor-like Immunoreactivity in Orbital and Pretibial Fibroblasts of Patients with Graves' Ophthalmopathy and Pretibial MyxedemaSemantic proximity Read ↗

Real-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissuesSemantic proximity Read ↗

Detection of TSH Receptor RNA in Cultured Fibroblasts from Patients with Graves' Ophthalmopathy and Pretibial DermopathySemantic proximity Read ↗

Thyrotropin Receptor Transcripts in Human Adipose TissueSemantic proximity Read ↗

Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissueSemantic proximity Read ↗

Immunopathogenesis of Graves’ ophthalmopathy: The role of the TSH receptorSemantic proximity Read ↗

Expression of Endogenous Putative TSH Binding Protein in Orbit.Semantic proximity Read ↗

Current evidence for and against the TSH receptor being the common antigen in Graves' disease and thyroid associated ophthalmopathy.Semantic proximity Read ↗

Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.Semantic proximity Read ↗

Thyroid-stimulating hormone receptor and its role in Graves' disease.Semantic proximity Read ↗

A heritable point mutation in an extracellular domain of the TSH receptor involved in the interaction with Graves' immunoglobulins.Semantic proximity Read ↗

Bovine thyrotropin receptor cDNA is characterized by full-length and truncated transcripts.Semantic proximity Read ↗

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