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Article

Detection of TSH Receptor RNA in Cultured Fibroblasts from Patients with Graves' Ophthalmopathy and Pretibial Dermopathy

1 Jan 1993

Abstract excerpt

Fibroblasts are target cells for the autoimmune process in Graves' ophthalmopathy and pretibial dermopathy. Because the autoantigen involved in the hyperthyroidism of Graves' disease is the TSH receptor, we sought to determine whether RNA encoding this receptor might be present in retroocular and pretibial fibroblasts. RNA was reverse transcribed and the resulting cDNA was amplified by the polymerase chain...

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Identifiers

PMID: 7509671
DOI: 10.1089/thy.1993.3.297

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Detection of TSH Receptor RNA in Cultured Fibroblasts from Patients with Graves' Ophthalmopathy and Pretibial DermopathyPMID 7509671Read ↗

TSH Receptor Transcripts and TSH Receptor-like Immunoreactivity in Orbital and Pretibial Fibroblasts of Patients with Graves' Ophthalmopathy and Pretibial MyxedemaSemantic proximity Read ↗

Real-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissuesSemantic proximity Read ↗

Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues.Semantic proximity Read ↗

Immunopathogenesis of Graves’ ophthalmopathy: The role of the TSH receptorSemantic proximity Read ↗

Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissueSemantic proximity Read ↗

Thyrotropin Receptor Transcripts in Human Adipose TissueSemantic proximity Read ↗

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.Semantic proximity Read ↗

A heritable point mutation in an extracellular domain of the TSH receptor involved in the interaction with Graves' immunoglobulins.Semantic proximity Read ↗

Lack of association between a polymorphism in the coding region of the thyrotropin receptor gene and Graves' disease.Semantic proximity Read ↗

[Analysis of the TSH receptor gene structure in Graves' disease by a restriction fragment length polymorphism (RFLP) study].Semantic proximity Read ↗

Genomic DNA analysis of thyrotropin receptor in a family with hereditary hyperthyroidism.Semantic proximity Read ↗

[Polymorphism of the 52 triplet gene (nucleotide 253) of the TSH receptor in Basedow-Graves patients and in healthy controls].Semantic proximity Read ↗

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