Article
Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression.
AIDS (London, England) - 15 Mar 1997
Khoo S H, Pepper L, Snowden N, Hajeer A H, Vallely P, Wilkins E G, Mandal B K, Ollier W E
Abstract excerpt
BACKGROUND: The rate of immunological deterioration and progression to AIDS differs markedly between HIV-positive individuals, and may be influenced by cofactors, HIV phenotype and host T-cell response. Tumour necrosis factor (TNF)-alpha and lymphotoxin stimulate HIV replication and may induce apoptosis of HIV-infected and uninfected lymphocytes in vitro, thus accelerating disease progression and CD4 depletion....
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