Article
Progression of HIV-related disease is associated with HLA DQ and DR alleles defined by restriction fragment length polymorphisms.
Tissue antigens - 1 May 1992
Donald J A, Rudman K, Cooper D W, Baumgart K W, Garsia R J, Gatenby P A, Rickard K A
Abstract excerpt
A cohort of 139 hemophiliacs was typed for HLA D region genes by means of restriction fragment length polymorphisms (RFLPs) detected by HLA DQ and DR gene probes. Disease progression was studied in the 65 HIV antibody-positive patients, who were infected by contaminated clotting factor before 1985. Strong associations were found between disease progression in HIV-infected patients and allelic DNA fragments...
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