Article
Progression of HIV-related disease is associated with HLA DQ and DR alleles defined by restriction fragment length polymorphisms.
Tissue antigens - 1 May 1992
Donald J A, Rudman K, Cooper D W, Baumgart K W, Garsia R J, Gatenby P A, Rickard K A
Abstract excerpt
A cohort of 139 hemophiliacs was typed for HLA D region genes by means of restriction fragment length polymorphisms (RFLPs) detected by HLA DQ and DR gene probes. Disease progression was studied in the 65 HIV antibody-positive patients, who were infected by contaminated clotting factor before 198...
Topics
- Alleles
- Blood Coagulation Disorders
- Cohort Studies
- DNA
- Disease Susceptibility
- Gene Frequency
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HIV Infections
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell, alpha-beta
- Severity of Illness Index