Article
Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region.
The Journal of clinical investigation - 15 Mar 1997
Suzuki K, Kuriyama M, Saito T, Ichinose A
Abstract excerpt
The apolipoprotein(a) (apo[a]) gene encodes a protein component of lipoprotein(a) [Lp(a)] whose plasma levels vary widely among individuals. Hyper-Lp(a)-emia constitutes a risk factor for thromboembolic disease. We previously subclassified the apo(a) gene into four allelic types (A-D) by polymorp...
Topics
- Alleles
- Apolipoprotein A-I
- Chloramphenicol O-Acetyltransferase
- Gene Deletion
- Gene Expression Regulation
- Humans
- Lipoprotein(a)
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Regulatory Sequences, Nucleic Acid