Article
Expressed hypervariable polymorphism of apolipoprotein (a).
American journal of human genetics - 1 Nov 1991
Kamboh M I, Ferrell R E, Kottke B A
Abstract excerpt
Elevated plasma lipoprotein (a) (LP(a] levels are an independent predictor of the development of premature atherosclerosis in humans. The LP(a) particle consists of two disulfide-linked proteins, apolipoprotein (APO) B and APO(a). The APO(a) is a highly glycosylated protein which carries the LP(a) antigen. Genetic polymorphism in the APO(a) molecule has been reported, and, depending on the sensitivity of the...
Topics
- Adult
- Alleles
- Apolipoproteins A
- Child
- Electrophoresis, Agar Gel
- Female
- Gene Frequency
- Humans
- Immunoblotting
- Male
- Pedigree
- Polymorphism, Genetic
