Article
Paroxysmal nocturnal hemoglobinuria: new insights from murine Pig-a-deficient hematopoiesis.
Proceedings of the Association of American Physicians - 1 Mar 1997
Devetten M P, Liu J M, Ling V, Weichold F F, Yu J, Medof M E, Young N S, Dunn D E
Abstract excerpt
A large fraction of the hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) are deficient in membrane expression of glycosylphosphatidylinositol-anchored proteins (GPI-APs). Current evidence suggests that this deficiency is sufficient to account for the hemolytic and th...
Topics
- Animals
- Disease Models, Animal
- Erythrocyte Membrane
- Hematopoiesis
- Hemoglobinuria, Paroxysmal
- Humans
- Membrane Proteins
- Mice
- Mice, Knockout
- Mutation
- Phenotype
- X Chromosome