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Article

Paroxysmal nocturnal hemoglobinuria: new insights from murine Pig-a-deficient hematopoiesis.

Proceedings of the Association of American Physicians - 1 Mar 1997

Devetten M P, Liu J M, Ling V, Weichold F F, Yu J, Medof M E, Young N S, Dunn D E

Abstract excerpt

A large fraction of the hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) are deficient in membrane expression of glycosylphosphatidylinositol-anchored proteins (GPI-APs). Current evidence suggests that this deficiency is sufficient to account for the hemolytic and thrombotic manifestations of this disease but not for its frequent association with aplastic anemia, an autoimmune...

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Identifiers

PMID: 9069578

Genes

GPI

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Paroxysmal nocturnal hemoglobinuria: new insights from murine Pig-a-deficient hematopoiesis.PMID 9069578Read ↗

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Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.Semantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria: An acquired genetic disease.Semantic proximity Read ↗

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