Molecular basis of paroxysmal nocturnal hemoglobinuria.

doi:10.1002/stem.140396

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Article

Molecular basis of paroxysmal nocturnal hemoglobinuria.

Stem cells (Dayton, Ohio) - 1 Jul 1996

Parker C J

Abstract excerpt

The purpose of this review is to summarize recent studies that have led to a more complete understanding of the molecular basis of paroxysmal nocturnal hemoglobinuria (PNH). Somatic mutations of PIG-A arising in pluripotent hematopoietic stem cells are necessary for the development of PNH. PIG-A...

Topics

Animals
Glycosylphosphatidylinositols
Hematopoiesis
Hematopoietic Stem Cells
Hemoglobinuria, Paroxysmal
Humans
Membrane Proteins
Mutation

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