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Article

Murine models of paroxysmal nocturnal hemoglobinuria.

Annals of the New York Academy of Sciences - 1 Jun 2002

Rosti Vittorio

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder characterized by chronic intravascular hemolysis, cytopenia, and an increased tendency to thrombosis. All patients with PNH studied so far have a somatic mutation of phosphatidyl inositol glycan complementation group A (PIG-A), an X-linked gene involved initially in the biosynthesis of the glycosyl phosphatidylinositol (GPI) molecule, which...

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Identifiers

PMID: 12095954
DOI: 10.1111/j.1749-6632.2002.tb04120.x

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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