Article
Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia.
Journal of clinical psychopharmacology - 1 Jun 1995
Arthur H, Dahl M L, Siwers B, Sjöqvist F
Abstract excerpt
The metabolism of many neuroleptics cosegregates catalyzed by the polymorphic cytochrome P450 CYP2D6. The population can be phenotyped into extensive metabolizers (EM) and poor metabolizers (PM) with respect to this enzyme's activity. PM are likely to achieve higher than average concentrations of...
Topics
- Adult
- Aged
- Antipsychotic Agents
- Dose-Response Relationship, Drug
- Dyskinesia, Drug-Induced
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Pilot Projects
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Schizophrenia
- Sensitivity and Specificity