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Article

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire

24 Dec 2012

Abstract excerpt

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is of pivotal importance for self-tolerance, with deficiency or unfavorable polymorphisms leading to autoimmune disease. Tolerance to self-antigens is achieved through thymic deletion of highly autoreactive conventional T (Tconv) cells and generation of FoxP3(+) regulatory T (Treg) cells. The main costimulatory molecule, CD28, augments the negative...

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PMID: 23267099
DOI: 10.1073/pnas.1208573110

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