Article
BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2003
Ginolhac Sophie M, Gad Sophie, Corbex Marilys, Bressac-De-Paillerets Brigitte, Chompret Agnès, Bignon Yves-Jean, Peyrat Jean-Philippe, Fournier Joelle, Lasset Christine, Giraud Sophie, Muller Danièle, Fricker Jean-Pierre, Hardouin Agnès, Berthet Pascaline, Maugard Christine, Nogues Catherine, Lidereau Rosette, Longy Michel, Olschwang Sylviane, Toulas Christine, Guimbaud Rosine, Yannoukakos Drakoulis, Szabo Csilla, Durocher Francine, Moisan Anne-Marie, Simard Jacques, Mazoyer Sylvie, Lynch Henry T, Goldgar David, Stoppa-Lyonnet Dominique, Lenoir Gilbert M, Sinilnikova Olga M
Abstract excerpt
Strong inter- and intrafamilial variation of penetrance of breast and ovarian cancer is observed in BRCA1 mutation carriers. The wild-type copy of the BRCA1 gene is a plausible candidate as a cancer risk modifier given that the residual function corresponding to the intact BRCA1 allele may influence the process of tumor formation in BRCA1 carriers. Indeed, growing evidence is now becoming available on impaired...
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