Article
[Functional screening of p53 status in tumor cells using Saccharomyces cerevisiae].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Feb 1997
Jia L Q, Ishioka C, Osada M, Gamo M, Shimodaira H, Suzuki T, Kanamaru R
Abstract excerpt
We have detected both germ-line and somatic p53 mutations in lymphocytes, cell lines and tumor tissues using a functional analysis of p53 tumor suppressor gene based on yeast transcription assay. Through our screening projects of the p53 gene, a number of missense p53 mutations were identified as loss-of-function mutations. This method, previously termed FASAY, is rapid, sensitive, less-expensive and can be...
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