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Article

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

15 May 1991

Abstract excerpt

To prospectively assess the role of MDR1 gene expression in patients with de novo acute myeloid leukemia (AML), levels of MDR1 RNA in blast cells were determined at diagnosis and correlated with treatment outcome in 63 patients. MDR1 RNA levels were negative in 29% and positive in 71% of the patients. The complete remission rate in response to induction chemotherapy was 89% for MDR1 RNA-negative patients and 53%...

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PMID: 2023272
DOI: 10.1093/jnci/83.10.708

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