Article
Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts.
Gastroenterology - 1 Feb 1998
Smits R, van der Houven van Oordt W, Luz A, Zurcher C, Jagmohan-Changur S, Breukel C, Khan P M, Fodde R
Abstract excerpt
BACKGROUND & AIMS: Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant predisposition to the formation of multiple colorectal adenomas. Moreover, patients with FAP are at high risk of developing several ex...
Topics
- Adenomatous Polyposis Coli
- Age of Onset
- Animals
- Cysts
- Disease Models, Animal
- Female
- Desmoid Tumors
- Genes, APC
- Genes, p53
- Loss of Heterozygosity
- Male
- Mice
- Mice, Inbred A
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mutation
- Neoplasms, Multiple Primary
- Phenotype