New genetic variants in the apoA-I and apoC-III genes and familial combined hyperlipidemia.

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Article

New genetic variants in the apoA-I and apoC-III genes and familial combined hyperlipidemia.

Journal of lipid research - 1 Feb 2001

Groenendijk M, Cantor R M, De Bruin T W, Dallinga-Thie G M

Abstract excerpt

Linkage and association between the apolipoprotein (apo) A-I/C-III/A-IV gene region on chromosome 11 and familial combined hyperlipidemia (FCHL) has been observed previously. Using sequence analysis two new allelic variants were identified, C(317) -T in intron 2 of the apoA-I gene and C(1100)-T in exon 3 of the apoC-III gene. These variants were studied in 30 FCHL probands, 159 hyperlipidemic relatives, 327...

Topics

Adult
Apolipoprotein A-I
Apolipoprotein C-III
Apolipoproteins C
Base Sequence
DNA Primers
Female
Genetic Variation
Genotype
Haplotypes
Humans
Hyperlipidemia, Familial Combined
Male
Middle Aged
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

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PMID: 11181747

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