Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.

doi:10.1200/JCO.2010.28.3390

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Article

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2010

Gutierrez Alejandro, Dahlberg Suzanne E, Neuberg Donna S, Zhang Jianhua, Grebliunaite Ruta, Sanda Takaomi, Protopopov Alexei, Tosello Valeria, Kutok Jeffery, Larson Richard S, Borowitz Michael J, Loh Mignon L, Ferrando Adolfo A, Winter Stuart S, Mullighan Charles G, Silverman Lewis B, Chin Lynda, Hunger Stephen P, Sallan Stephen E, Look A Thomas

Abstract excerpt

PURPOSE: To identify children with T-cell acute lymphoblastic leukemia (T-ALL) at high risk of induction chemotherapy failure by using DNA copy number analysis of leukemic cells collected at diagnosis. PATIENTS AND METHODS: Array comparative genomic hybridization (CGH) was performed on genomic DNA extracted from diagnostic lymphoblasts from 47 children with T-ALL treated on Children's Oncology Group Study P9404...

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Identifiers

PMID: 20644084
DOI: 10.1200/JCO.2010.28.3390
PMCID: PMC2940399

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