Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain.

Development (Cambridge, England) - 1 Mar 1997

Lee S M, Danielian P S, Fritzsch B, McMahon A P

Abstract excerpt

The developing vertebrate mesencephalon shows a rostrocaudal gradient in the expression of a number of molecular markers and in the cytoarchitectonic differentiation of the tectum, where cells cease proliferating and differentiate in a rostral to caudal progression. Tissue grafting experiments have implicated cell signalling by the mesencephalic-metencephalic (mid-hindbrain) junction (or isthmus) in orchestrating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to DNA-Binding Proteins
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutagenesis

Share to Nuclear Proteins

Share to Phenotype

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 9056772
DOI: 10.1242/dev.124.5.959

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain.PMID 9056772Read ↗

Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate.Semantic proximity Read ↗

Involvement of Wnt-1 in the formation of the mes/metencephalic boundary.Semantic proximity Read ↗

Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection.Semantic proximity Read ↗

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.Semantic proximity Read ↗

The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo.Semantic proximity Read ↗

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.Semantic proximity Read ↗

Lhx2 regulates the development of the forebrain hem system.Semantic proximity Read ↗

Two parallel lineage-committed progenitors contribute to the developing brainSemantic proximity Read ↗

Temporal sequence of gene expression leading caudal prosencephalon to develop a midbrain/hindbrain phenotype.Semantic proximity Read ↗

The role of the Eph-ephrin signalling system in the regulation of developmental patterning.Semantic proximity Read ↗

The caudal limit of Otx2 expression positions the isthmic organizer.Semantic proximity Read ↗

Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.