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Article

A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes.

Nature genetics - 1 Mar 1997

Våge D I, Lu D, Klungland H, Lien S, Adalsteinsson S, Cone R D

Abstract excerpt

Agouti and extension are two genes that control the production of yellow-red (phaeomelanin) and brown-black (eumelanin) pigments in the mammalian coat. Extension encodes the melanocyte-stimulating hormone receptor (MC1R) while agouti encodes a peptide antagonist of the receptor. In the mouse, extension is epistatic to agouti, hence dominant mutants of the MC1R encoding constitutively active receptors are not...

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PMID: 9054949
DOI: 10.1038/ng0397-311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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