Stability changes upon mutation of solvent-accessible residues in proteins evaluated by database-derived potentials.

doi:10.1006/jmbi.1996.0226

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Article

Stability changes upon mutation of solvent-accessible residues in proteins evaluated by database-derived potentials.

Journal of molecular biology - 19 Apr 1996

Gilis D, Rooman M

Abstract excerpt

The stability changes in peptides and proteins caused by the substitution of a single amino acid, which can be measured experimentally by the change in folding free energy, are evaluated here using effective potentials derived from known protein structures. The analysis is focused on mutations of...

Topics

Algorithms
Bacterial Proteins
Databases, Factual
Enzyme Stability
Micrococcal Nuclease
Muramidase
Mutation
Peptides
Plant Proteins
Protein Conformation
Protein Denaturation
Protein Folding
Proteins
Ribonucleases
Solvents
Thermodynamics

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