Article
Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group.
Genome research - 1 Feb 1997
Ghosh S, Karanjawala Z E, Hauser E R, Ally D, Knapp J I, Rayman J B, Musick A, Tannenbaum J, Te C, Shapiro S, Eldridge W, Musick T, Martin C, Smith J R, Carpten J D, Brownstein M J, Powell J I, Whiten R, Chines P, Nylund S J, Magnuson V L, Boehnke M, Collins F S
Abstract excerpt
Large-scale genotyping is required to generate dense identity-by-descent maps to map genes for human complex disease. In some studies the number of genotypes needed can approach or even exceed 1 million. Generally, linkage and linkage disequilibrium analyses depend on clear allele identification and subsequent allele frequency estimation. Accurate grouping or categorization of each allele in the sample (allele...
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