Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12.

American journal of human genetics - 1 May 2006

Gaffney Patrick M, Langefeld Carl D, Graham Robert R, Ortmann Ward A, Williams Adrienne H, Rodine Peter R, Moser Kathy L, Behrens Timothy W

Abstract excerpt

The presence of systemic lupus erythematosus (SLE) susceptibility genes on chromosome 20 is suggested by the observation of genetic linkage in several independent SLE family collections. To further localize the genetic effects, we typed 59 microsatellites in the two best regions, as defined by genome screens. Genotypes were analyzed for statistical linkage and/or association with SLE, by use of a combination of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 16
Share to Chromosomes, Human, Pair 20

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Family Health

Share to Lod Score

Share to Lupus Erythematosus, Systemic

Share to Physical Chromosome Mapping

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 16642431
DOI: 10.1086/503686
PMCID: PMC1474034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12.PMID 16642431Read ↗

Fine mapping chromosome 16q12 in a collection of 231 systemic lupus erythematosus sibpair and multiplex families.Semantic proximity Read ↗

A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families.Semantic proximity Read ↗

Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families.Semantic proximity Read ↗

Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans.Semantic proximity Read ↗

Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23.Semantic proximity Read ↗

Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.Semantic proximity Read ↗

Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus.Semantic proximity Read ↗

Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis.Semantic proximity Read ↗

Haplotype associations define target regions for susceptibility loci in systemic lupus erythematosus.Semantic proximity Read ↗

Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry.Semantic proximity Read ↗

The genetics of systemic lupus erythematosus: putting the pieces together.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.