Article
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians.
American journal of human genetics - 1 Mar 1997
Sakul H, Pratley R, Cardon L, Ravussin E, Mott D, Bogardus C
Abstract excerpt
Susceptibility to non-insulin-dependent diabetes mellitus (NIDDM) is largely genetically determined. In Pima Indians, obesity, insulin resistance, and a low acute insulin response (AIR) to an intravenous glucose infusion are each predictors of the disease. To ascertain whether these phenotypes are genetically determined, we estimated their familiality in nondiabetic Pima Indians with a maximum-likelihood method....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.